With the rapid expansion of technology available for spinal disorders and with advanced diagnostic modalities, the field of spinal surgery has attained an enormous status. This has been possible due to the plethora of research activities related to spine across the globe. Our organization has been involved in intensive research work in various aspects in spinal disorders including deformity, trauma, tumor, infection, and degenerative disorders. The academic chores and research tasks are regulated and managed by Dr. Saumyajit Basu, who serves as the Director of Fellowships in Spine Surgery, along with other doctors in the team. In the process we won various research awards and more than 30 national/international publications have been possible. We hope to further enhance our potentialities in this field and contribute to the advancement of science behind the spine. Here are some of our current active projects-
1. Study of spinal deformities in parkinsonism
Parkinson’s disease is a neurodegenerative disorder typically found in the geriatric age group. Many of them develop spinal deformities and gets tilted over to one side or stoops forward. The study is based on patients suffering from Parkinsonism, obtaining full spine standing radiographs and measuring the amount of deformity. This is to be corelated with existing osteoporosis in these individuals (for which a DEXA scan is done for each of them). It also is to be corelated with the severity of the disease vis-a vis the ongoing anti Parkinson’s medication. Status – Patient recruitment nearly completed. Analysis going on.
2. Role of PET-CT scan in Spondylolysis and low-grade lytic Spondylolisthesis
Patients with defect in the pars (a particular part of the vertebra) of L5 or L4, who presents with back pain is being studied. X-ray CT scan MRI findings are recorded. They are then subjected to whole body PET CT scan and the metabolic activity in the region of the pars defect is noted. The correlation of patients’ symptoms and the metabolic activity will be statically worked out. Status – Patient recruitment going on.
3. Role of Tractography in the diagnosis and prognostication of TB spine patients
This is a study to demonstrate the efficacy of a particular sequence in MRI – known as Diffusion Tensor Imaging (DTI) or Tractography in which the various tracts of the spinal cord are imaged. All patients admitted for surgery for TB spine was subjected to MRI and tractography was done and the severity of neural damage was recorded. These patients were then followed up after surgery to note the improvement. After 1 year, the neurological improvement was correlated with the Tractography findings to see whether the latter was predictive for outcome or not. Status – Study completed; efforts to publish the same going on.
4. Study of microbiome of the cervical disc
There has been a recent spurt in study of degenerative changes in the lumbar disc from a microbiological perspective. To this end, microorganisms have been cultured from the normal and abnormal lumbar discs through DNA analysis. However, there is no similar data published for cervical discs. The current research focuses on a description of the microbiome of the human cervical disc which are in various stages of degeneration. Surgical specimens of cervical discs would be collected from patients undergoing anterior cervical decompression surgeries and will be stored at very low temperatures and followed by DNA extraction and microbiome analysis. Status – Ethics Committee approval obtained, and patient recruitment would be started soon.
5. The predictive value of intraoperative neural monitoring data changes in patients undergoing surgery for dorsal or cervical myelopathy in the perspective of neurological improvement
Literature is sparse regarding the functional and neurological improvement of patients undergoing decompressive surgeries for thoracic and cervical myelopathy as corelated to the data obtained during neuromonitoring at surgery. The research protocol includes baseline and subsequent recordings of SSEPs and MEPs and comparing it with the final recordings at the end of closure. The difference would be correlated with the neurological and functional improvement of patients at the end of 3, 6 and 12 months. Status – Ethics Committee approval obtained; patient recruitment started.
Take a look at our publications…